Metabolites as regulators of insulin sensitivity and metabolism
Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018 - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
Understanding FAHFAs: From structure to metabolic regulation
K Brejchova, L Balas, V Paluchova, M Brezinova… - Progress in lipid …, 2020 - Elsevier
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …
attention of many researches to their biological effects. Although FAHFAs were originally …
ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …
Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health
M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …
contains both signaling mediators and structural components of lipid biofilms in humans …
Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of
biologically active lipids. Here we identify the linoleic acid ester of 13-hydroxy linoleic acid …
biologically active lipids. Here we identify the linoleic acid ester of 13-hydroxy linoleic acid …
PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms
Palmitic acid esters of hydroxy stearic acids (PAHSAs) are bioactive lipids with
antiinflammatory and antidiabetic effects. PAHSAs reduce ambient glycemia and improve …
antiinflammatory and antidiabetic effects. PAHSAs reduce ambient glycemia and improve …
Comprehensive screening and identification of fatty acid esters of hydroxy fatty acids in plant tissues by chemical isotope labeling-assisted liquid chromatography …
QF Zhu, JW Yan, TY Zhang, HM Xiao… - Analytical …, 2018 - ACS Publications
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a new class of lipid mediators with
promising anti-diabetic and anti-inflammatory properties. Comprehensive screening and …
promising anti-diabetic and anti-inflammatory properties. Comprehensive screening and …
Sequestration of 9-hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell …
Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of
them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through …
them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through …
Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with
antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with …
antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with …
PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice
I Syed, MFR de Celis, JF Mohan… - The Journal of …, 2019 - Am Soc Clin Investig
Palmitic acid esters of hydroxy stearic acids (PAHSAs) are endogenous antidiabetic and
antiinflammatory lipids. Here, we show that PAHSAs protect against type 1 diabetes (T1D) …
antiinflammatory lipids. Here, we show that PAHSAs protect against type 1 diabetes (T1D) …