Metabolites as regulators of insulin sensitivity and metabolism

Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018 - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Understanding FAHFAs: From structure to metabolic regulation

K Brejchova, L Balas, V Paluchova, M Brezinova… - Progress in lipid …, 2020 - Elsevier
The discovery of branched fatty acid esters of hydroxy fatty acids (FAHFAs) in humans draw
attention of many researches to their biological effects. Although FAHFAs were originally …

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

R Patel, A Santoro, P Hofer, D Tan, M Oberer… - Nature, 2022 - nature.com
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health

M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …

Linoleic acid esters of hydroxy linoleic acids are anti-inflammatory lipids found in plants and mammals

MJ Kolar, S Konduri, T Chang, H Wang… - Journal of Biological …, 2019 - ASBMB
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a recently discovered class of
biologically active lipids. Here we identify the linoleic acid ester of 13-hydroxy linoleic acid …

PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms

P Zhou, A Santoro, OD Peroni… - The Journal of …, 2019 - Am Soc Clin Investig
Palmitic acid esters of hydroxy stearic acids (PAHSAs) are bioactive lipids with
antiinflammatory and antidiabetic effects. PAHSAs reduce ambient glycemia and improve …

Comprehensive screening and identification of fatty acid esters of hydroxy fatty acids in plant tissues by chemical isotope labeling-assisted liquid chromatography …

QF Zhu, JW Yan, TY Zhang, HM Xiao… - Analytical …, 2018 - ACS Publications
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a new class of lipid mediators with
promising anti-diabetic and anti-inflammatory properties. Comprehensive screening and …

Sequestration of 9-hydroxystearic acid in FAHFA (fatty acid esters of hydroxy fatty acids) as a protective mechanism for colon carcinoma cells to avoid apoptotic cell …

JP Rodríguez, C Guijas, AM Astudillo, JM Rubio… - Cancers, 2019 - mdpi.com
Hydroxy fatty acids are known to cause cell cycle arrest and apoptosis. The best studied of
them, 9-hydroxystearic acid (9-HSA), induces apoptosis in cell lines by acting through …

Distinct biological activities of isomers from several families of branched fatty acid esters of hydroxy fatty acids (FAHFAs)

P Aryal, I Syed, J Lee, R Patel, AT Nelson… - Journal of lipid …, 2021 - ASBMB
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are endogenous lipids with
antidiabetic and anti-inflammatory effects. Each FAHFA family consists of esters with …

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

I Syed, MFR de Celis, JF Mohan… - The Journal of …, 2019 - Am Soc Clin Investig
Palmitic acid esters of hydroxy stearic acids (PAHSAs) are endogenous antidiabetic and
antiinflammatory lipids. Here, we show that PAHSAs protect against type 1 diabetes (T1D) …