Amino acids play central roles in cancer progression beyond their function as building
blocks for protein synthesis. Thus, targeting amino acid acquisition and utilization has been …

L-asparaginase, which hydrolyzes asparagine into aspartic acid and ammonia, is frequently
used to treat acute lymphoblastic leukaemia in children. When combined with other …

Rationale: Recent studies indicate that microglial activation and the resulting inflammatory
response could be potential targets of adjuvant therapy for ischemic stroke. Many studies …

Abstract Glycogen synthase kinase 3 (GSK-3) consists of two isoforms (α and β) that were
originally linked to glucose metabolism regulation. However, GSK-3 is also involved in …

Huntington's disease (HD) is caused by an expansion of a CAG repeat in the gene that
encodes the huntingtin protein (HTT). The exact function of HTT is still not fully understood …

Apoptosis, classically initiated by caspase pathway activation, plays a prominent role during
normal brain development as well as in neurodegeneration. The noncanonical, nonlethal …

Most leukemia patients experience little benefit from immunotherapy, in part due to the
immunosuppressive bone marrow microenvironment. Various metabolic mechanisms …

Asparagine, an important amino acid in mammals, is produced in several organs and is
widely used for the production of other nutrients such as glucose, proteins, lipids, and …

Acute leukemias, classified as acute myeloid leukemia and acute lymphoblastic leukemia,
represent the most prevalent hematologic tumors in adolescent and young adults. In recent …

Purpose Uveal melanoma (UVM) is a rare yet malignant ocular tumor that metastases in
approximately half of all patients, with the majority of those developing metastasis typically …