Primary tumors actively and specifically prime pre-metastatic niches (PMNs), the future sites
of organotropic metastasis, preparing these distant microenvironments for disseminated …

Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

Neutrophil recruitment is an important early step in controlling tissue infections or injury.
Here, we report that this influx depends on both tissue-resident mast cells and …

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are
characterised by aberrant immunological responses leading to chronic inflammation without …

Infection or sterile inflammation triggers site-specific attraction of leukocytes. Leukocyte
recruitment is a process comprising several steps orchestrated by adhesion molecules …

In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions
(paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that …

The leukocyte integrin α M β 2/Mac-1 appears to support the inflammatory response through
multiple ligands, but local engagement of fibrin (ogen) may be particularly important for …

The innate immune system responds to inflammation, infection and injury by recruiting
neutrophils and other leukocytes. These cells are able to leave the intravascular …

Neutrophils are the first immune cells to migrate into infected tissue sites. Therefore an
important step in the initiation of an immune response is the synthesis of the neutrophil …