Intestinal transplantation (ITx) remains a lifesaving option for patients suffering from
irreversible intestinal failure and complications from total parenteral nutrition. Since its …

The main role of red blood cells is oxygen-transportation. However, recent studies have
unveiled immunomodulatory functions for their immature counterparts, CD71+ erythroid …

The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …

Abstract Resident memory CD8 T (Trm) cells have been shown to provide effective
protective responses in the small intestine (SI) in mice. A better understanding of the …

Tissue-resident memory T (T RM) cells provide key adaptive immune responses in infection,
cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal T RM …

The generation of antibodies against donor-specific major histocompatibility complex (MHC)
antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that …

In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism
often develops. Donor T cell macrochimerism (≥ 4%) frequently occurs without graft-versus …

T cells play a key role in determining allograft function by mediating allogeneic immune
responses to cause rejection, and recent work pointed their role in mediating tolerance in …

Highlights•Rare HSPCs are found in blood and tissues such as spleen, liver, and
lung.•Extramedullary HSPCs contribute to blood formation under stress conditions.•The …

Innate immune cells represent the first line of cellular immunity, comprised of both circulating
and tissue-resident natural killer cells and innate lymphoid cells. These innate lymphocytes …