[HTML][HTML] Intestinal transplant immunology and intestinal graft rejection: from basic mechanisms to potential biomarkers
M Rumbo, M Oltean - International Journal of Molecular Sciences, 2023 - mdpi.com
Intestinal transplantation (ITx) remains a lifesaving option for patients suffering from
irreversible intestinal failure and complications from total parenteral nutrition. Since its …
irreversible intestinal failure and complications from total parenteral nutrition. Since its …
Neglected cells: immunomodulatory roles of CD71+ erythroid cells
S Elahi - Trends in immunology, 2019 - cell.com
The main role of red blood cells is oxygen-transportation. However, recent studies have
unveiled immunomodulatory functions for their immature counterparts, CD71+ erythroid …
unveiled immunomodulatory functions for their immature counterparts, CD71+ erythroid …
Plasticity of intragraft alloreactive T cell clones in human gut correlates with transplant outcomes
The site of transition between tissue-resident memory (TRM) and circulating phenotypes of T
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
cells is unknown. We integrated clonotype, alloreactivity, and gene expression profiles of …
[HTML][HTML] Resident memory CD8 T cells persist for years in human small intestine
R Bartolomé-Casado, OJB Landsverk… - The Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Resident memory CD8 T (Trm) cells have been shown to provide effective
protective responses in the small intestine (SI) in mice. A better understanding of the …
protective responses in the small intestine (SI) in mice. A better understanding of the …
[HTML][HTML] Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets
Tissue-resident memory T (T RM) cells provide key adaptive immune responses in infection,
cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal T RM …
cancer, and autoimmunity. However, transcriptional heterogeneity of human intestinal T RM …
Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation
X Charmetant, CC Chen, S Hamada… - Science Translational …, 2022 - science.org
The generation of antibodies against donor-specific major histocompatibility complex (MHC)
antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that …
antigens, a type of donor-specific antibodies (DSAs), after transplantation requires that …
[HTML][HTML] Lymphohematopoietic graft-versus-host responses promote mixed chimerism in patients receiving intestinal transplantation
J Fu, J Zuber, B Shonts, A Obradovic… - The Journal of …, 2021 - Am Soc Clin Investig
In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism
often develops. Donor T cell macrochimerism (≥ 4%) frequently occurs without graft-versus …
often develops. Donor T cell macrochimerism (≥ 4%) frequently occurs without graft-versus …
[HTML][HTML] Analysis of T-cell receptor repertoire in transplantation: fingerprint of T cell-mediated alloresponse
G Tian, M Li, G Lv - Frontiers in Immunology, 2022 - frontiersin.org
T cells play a key role in determining allograft function by mediating allogeneic immune
responses to cause rejection, and recent work pointed their role in mediating tolerance in …
responses to cause rejection, and recent work pointed their role in mediating tolerance in …
[HTML][HTML] Hematopoietic stem and progenitor cells outside the bone marrow: where, when, and why
N Mende, E Laurenti - Experimental hematology, 2021 - Elsevier
Highlights•Rare HSPCs are found in blood and tissues such as spleen, liver, and
lung.•Extramedullary HSPCs contribute to blood formation under stress conditions.•The …
lung.•Extramedullary HSPCs contribute to blood formation under stress conditions.•The …
Deciphering the localization and trajectory of human natural killer cell development
E Hegewisch-Solloa, AP Nalin… - Journal of Leukocyte …, 2023 - academic.oup.com
Innate immune cells represent the first line of cellular immunity, comprised of both circulating
and tissue-resident natural killer cells and innate lymphoid cells. These innate lymphocytes …
and tissue-resident natural killer cells and innate lymphoid cells. These innate lymphocytes …