During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Structural analysis of modern pharmaceutical practices allows for the identification of two
rapidly growing trends: the introduction of tailor‐made amino acids and the exploitation of …

Spirocycles are ring systems in which two rings are fused through a single atom, referred to
as the spiro atom. The ethylene glycol ketal of cyclohexanone is an example of a well-known …

One of the most exciting developments in antiviral research has been the discovery of the
direct-acting antivirals (DAAs) that effectively cure chronic hepatitis C virus (HCV) infections …

Drug resistance is prevalent across many diseases, rendering therapies ineffective with
severe financial and health consequences. Rather than accepting resistance after the fact …

Highlights•The development of numerous HCV NS3/4a protease inhibitors that entered
clinical trials is discussed.•Structural breakthroughs that influenced the field are …

A significant number of antiviral agents used in clinical practice are amino acids, short
peptides, or peptidomimetics. Among them, several HIV protease inhibitors (eg lopinavir …

A one-pot, catalyst-free route to spiro [dihydroquinoline-naphthofuranone] compounds from
isatins through ring-opening and cyclization processes in water is disclosed. Hydrogen …

Human immunodeficiency virus type-1 and hepatitis C virus (HIV/HCV) coinfection occurs
when a patient is simultaneously infected with both human immunodeficiency virus type-1 …

Hepatitis C viral (HCV) infection is the leading cause of liver failure and still represents a
global health burden. Over the past decade, great advancements made HCV curable, and …