One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Circular RNAs represent a large class of non-coding RNAs that are extensively expressed in
mammals. However, the functions of circular RNAs are largely unknown. We recently …

Paclitaxel (PTX) is widely used in the front-line chemotherapy for gastric cancer (GC), but
resistance limits its use. Due to the lack of proper models, mechanisms underlying PTX …

Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M
checkpoint, is expressed in many cells and plays an important role in cell cycle control …

Paclitaxel (PTX) is widely used as a front-line chemotherapy for breast cancer treatment.
However, its clinical applications are limited by the development of chemoresistance. The …

High-grade serous ovarian cancer (HGSOC) is the most lethal gynecological malignancy.
However, the molecular mechanisms underlying HGSOC development, progression …

Debulking surgery followed by chemotherapy are the standard of care for high-grade serous
carcinoma. After an initial good response to treatment, the majority of patients relapse with a …

Serous ovarian cancer (SOC) is the most lethal gynecological cancer. Clinical studies have
revealed an association between tumor stage and grade and clinical prognosis …

Abstract Poly (ADP-ribose) polymerase (PARP) has recently emerged as a central mediator
in cancer resistance against numerous anticancer agents to include chemotherapeutic …