Many human birth defects and neurodevelopmental disorders are caused by loss-of-function
mutations in a single copy of transcription factor (TF) and chromatin regulator genes …

The prevalence of environmental problems and the increasing risk of human exposure to
environmental pollutants have become a global concern. The increasing environmental …

Purpose Existing resources that characterize the essentiality status of genes are based on
either proliferation assessment in human cell lines, viability evaluation in mouse knockouts …

Background Poor translation between in vitro and clinical studies due to the cells/humans
discrepancy in drug target perturbation effects leads to safety failures in clinical trials, thus …

Mouse models have been engineered to reveal the biological mechanisms of human
diseases based on an assumption. The assumption is that orthologous genes underlie …

Mutations in ARID1B, a member of the mSWI/SNF complex, cause severe
neurodevelopmental phenotypes with elusive mechanisms in humans. The most common …

Pre-clinical models are critical in gaining mechanistic and biological insights into disease
progression. Recently, patient-derived organoid models have been developed to facilitate …

In endocrinology, there are many similarities in the regulation of gene expression between
alleles, paralogous or orthologous genes, at the genetic or epigenetic level. However, there …

Chromatin accessibility assays are central to the genome-wide identification of gene
regulatory elements associated with transcriptional regulation. However, the data have …

Research organisms provide invaluable insights into human biology and diseases, serving
as essential tools for functional experiments, disease modeling, and drug testing. However …