Cytoplasmic intermediate filaments in cell biology
S Etienne-Manneville - Annual review of cell and …, 2018 - annualreviews.org
Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …
stability, intrinsic mechanical properties, and cell type–specific expression patterns …
Keratins in health and disease
The cytoprotective keratins (K) compose the intermediate filaments of epithelial cells and
their inherited and spontaneous mutations give rise to keratinopathies. For example …
their inherited and spontaneous mutations give rise to keratinopathies. For example …
Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma
Q Zhong, J Huang, J Wei, R Wu - Cancer cell international, 2019 - Springer
Abstract Background Circular RNA (circRNA) CDR1as plays an important role in the
occurrence and development of human tumors. The purpose of this study is to investigate …
occurrence and development of human tumors. The purpose of this study is to investigate …
[HTML][HTML] c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis
It is well known that c-Src has important roles in tumorigenesis. However, it remains unclear
whether c-Src contributes to metabolic reprogramming. Here we find that c-Src can interact …
whether c-Src contributes to metabolic reprogramming. Here we find that c-Src can interact …
Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2, 4-diones: Design, synthesis and in …
Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar levels and
related complications. This study focuses on harnessing and integrating fragment-based …
related complications. This study focuses on harnessing and integrating fragment-based …
Intermediate filaments as organizers of cellular space: how they affect mitochondrial structure and function
N Schwarz, RE Leube - Cells, 2016 - mdpi.com
Intermediate filaments together with actin filaments and microtubules form the cytoskeleton,
which is a complex and highly dynamic 3D network. Intermediate filaments are the major …
which is a complex and highly dynamic 3D network. Intermediate filaments are the major …
Validation of current good manufacturing practice compliant human pluripotent stem cell-derived hepatocytes for cell-based therapy
Recent advancements in the production of hepatocytes from human pluripotent stem cells
(hPSC-Heps) afford tremendous possibilities for treatment of patients with liver disease …
(hPSC-Heps) afford tremendous possibilities for treatment of patients with liver disease …
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
CGA Stenvall, M Tayyab, TJ Grönroos… - Cellular and Molecular …, 2022 - Springer
Abstract Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with
proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in …
proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in …
AKT2 phosphorylation of hexokinase 2 at T473 promotes tumorigenesis and metastasis in colon cancer cells via NF-κB, HIF1α, MMP2, and MMP9 upregulation
H Li, S Lu, Y Chen, L Zheng, L Chen, H Ding, J Ding… - Cellular signalling, 2019 - Elsevier
It has been well-established that AKT2 plays an important role in the development and
progression of colon cancer; however, its precise function remains unclear. In the present …
progression of colon cancer; however, its precise function remains unclear. In the present …
Clear cell hepatocellular carcinoma: origin, metabolic traits and fate of glycogenotic clear and ground glass cells
P Bannasch, S Ribback, Q Su, D Mayer - Hepatobiliary & Pancreatic …, 2017 - Elsevier
Clear cell hepatocellular carcinoma (CCHCC) has hitherto been considered an uncommon,
highly differentiated variant of hepatocellular carcinoma (HCC) with a relatively favorable …
highly differentiated variant of hepatocellular carcinoma (HCC) with a relatively favorable …