Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids
Abnormal assembly of tau, α-synuclein, TDP-43 and amyloid-β proteins into amyloid
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
filaments defines most human neurodegenerative diseases. Genetics provides a direct link …
Neuropathology and molecular diagnosis of Synucleinopathies
Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …
Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
α-Synuclein aggregation nucleates through liquid–liquid phase separation
Abstract α-Synuclein (α-Syn) aggregation and amyloid formation is directly linked with
Parkinson's disease pathogenesis. However, the early events involved in this process …
Parkinson's disease pathogenesis. However, the early events involved in this process …
Discriminating α-synuclein strains in Parkinson's disease and multiple system atrophy
Synucleinopathies are neurodegenerative diseases that are associated with the misfolding
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …
and aggregation of α-synuclein, including Parkinson's disease, dementia with Lewy bodies …
Structures of α-synuclein filaments from multiple system atrophy
M Schweighauser, Y Shi, A Tarutani, F Kametani… - Nature, 2020 - nature.com
Synucleinopathies, which include multiple system atrophy (MSA), Parkinson's disease,
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
Parkinson's disease with dementia and dementia with Lewy bodies (DLB), are human …
High-resolution structure and strain comparison of infectious mammalian prions
Within the extensive range of self-propagating pathologic protein aggregates of mammals,
prions are the most clearly infectious (eg,∼ 10 9 lethal doses per milligram). The structures …
prions are the most clearly infectious (eg,∼ 10 9 lethal doses per milligram). The structures …
A biological definition of neuronal α-synuclein disease: towards an integrated staging system for research
Parkinson's disease and dementia with Lewy bodies are currently defined by their clinical
features, with α-synuclein pathology as the gold standard to establish the definitive …
features, with α-synuclein pathology as the gold standard to establish the definitive …
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
B Falcon, J Zivanov, W Zhang, AG Murzin, HJ Garringer… - Nature, 2019 - nature.com
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy that is
associated with repetitive head impacts or exposure to blast waves. First described as punch …
associated with repetitive head impacts or exposure to blast waves. First described as punch …
Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel
Abstract α-Synuclein (aSyn) fibrillar polymorphs have distinct in vitro and in vivo seeding
activities, contributing differently to synucleinopathies. Despite numerous prior attempts, how …
activities, contributing differently to synucleinopathies. Despite numerous prior attempts, how …