Colon cancer poses a complex and substantial global health challenge, necessitating
innovative therapeutic approaches. Chalcones, a versatile class of compounds with diverse …

Despite significant advancements in chemotherapy, effective treatments for advanced
cancer stages remain largely elusive due to chemoresistance. Resistance to anticancer …

Hepatocellular carcinoma (HCC) exhibits high mortality rates in the advanced stage (>
90%). Sorafenib (SORA) is a targeted therapy approved for the treatment of advanced HCC; …

Arthritis, a global health burden comprising osteoarthritis and rheumatoid arthritis, demands
advanced therapeutic approaches. In this context, flavonoids, a diverse group of naturally …

Cancer continues to be a prominent issue in healthcare systems, resulting in approximately
9.9 million fatalities in 2020. It is the second most common cause of death after …

Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous
biological functions, including metabolism. Because of the potential implications of targeted …

Piperine, an active plant alkaloid from black pepper (Piper nigrum), has several
pharmacological effects, namely antioxidant, anti-inflammatory and immunomodulatory …

Skin cancer is the most widespread type of malignant tumor representing a major public
health concern. Considering the numerous side effects associated with conventional …

Background Colorectal cancer (CRC) is a prevalent malignancy and poses a significant
clinical challenge. Piperine, an alkaloid molecule extracted from Piper nigrum and Piper …

Docetaxel (DTX) resistance poses a significant challenge in the treatment of prostate cancer
(PCa), often leading to chemotherapy failure. This study investigates the ability of piperine, a …