The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

Bacterial genomes evolve through mutations, rearrangements or horizontal gene transfer.
Besides the core genes encoding essential metabolic functions, bacterial genomes also …

Although phthiocerol dimycocerosates (DIM) are major virulence factors of Mycobacterium
tuberculosis (Mtb), the causative agent of human tuberculosis, little is known about their …

Tuberculosis is a distinctive disease in which the causative agent, Mycobacterium
tuberculosis, can persist in humans for decades by avoiding clearance from host immunity …

A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …

Mycobacterium tuberculosis (Mtb) uses efficient strategies to evade the eradication by
professional phagocytes, involving—as recently confirmed—escape from phagosomal …

Acidification of the phagosome is considered to be a major mechanism used by
macrophages against bacteria, including Mycobacterium tuberculosis (Mtb). Mtb blocks …

The mycobacterial PE/PPE proteins have attracted much interest since their formal
identification just over a decade ago. It has been widely speculated that these proteins may …

A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has
been elusive in part because of imperfect surrogate laboratory hosts, each with its own …

Responses to acid have been studied extensively in enteric pathogens, such as Escherichia
coli, Vibrio cholerae, and Helicobacter pylori that encounter the extremely low pH (pH 2 to 3) …