Homocysteine modification in protein structure/function and human disease

H Jakubowski - Physiological reviews, 2019 - journals.physiology.org
Epidemiological studies established that elevated homocysteine, an important intermediate
in folate, vitamin B12, and one carbon metabolism, is associated with poor health, including …

Protein N-homocysteinylation: From cellular toxicity to neurodegeneration

GS Sharma, T Kumar, TA Dar, LR Singh - Biochimica et Biophysica Acta …, 2015 - Elsevier
Abstract Background Homocysteine (Hcy) is a sulfur containing non-protein amino acid that
occupies a central role in metabolism of thiol compounds. The past decade had noticed an …

[图书][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1‐dependent epigenetic regulation of mTOR …

Ł Witucki, H Jakubowski - Journal of Inherited Metabolic …, 2023 - Wiley Online Library
The loss of cystathionine β‐synthase (CBS), an important homocysteine (Hcy)‐metabolizing
enzyme or the loss of PHF8, an important histone demethylase participating in epigenetic …

N‐homocysteinylation of α‐synuclein promotes its aggregation and neurotoxicity

L Zhou, T Guo, L Meng, X Zhang, Y Tian, L Dai… - Aging …, 2023 - Wiley Online Library
The aggregation of α‐synuclein plays a pivotal role in the pathogenesis of Parkinson's
disease (PD). Epidemiological evidence indicates that high level of homocysteine (Hcy) is …

Application of W-band 19 F electron nuclear double resonance (ENDOR) spectroscopy to distance measurement using a trityl spin probe and a fluorine label

NB Asanbaeva, AA Sukhanov, AA Diveikina… - Physical Chemistry …, 2022 - pubs.rsc.org
Recently, Marina Bennati and coworkers (M. Bennati et al., Angew. Chem., Int. Ed., 2020, 59,
373–379., M. Bennati et al., J. Magn. Reson., 2021, 333, 107091) proposed to use electron …

The human paraoxonase gene cluster as a target in the treatment of atherosclerosis

ZG She, HZ Chen, Y Yan, H Li, DP Liu - Antioxidants & redox …, 2012 - liebertpub.com
The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2,
and PON3. Originating from the same fungus lactonase precursor, all of the three PON …

Homocystinuria: therapeutic approach

T Kumar, GS Sharma, LR Singh - Clinica Chimica Acta, 2016 - Elsevier
Homocystinuria is a disorder of sulfur metabolism pathway caused by deficiency of
cystathionine β-synthase (CBS). It is characterized by increased accumulation of …

Chemical modifications of insulin: Finding a compromise between stability and pharmaceutical performance

M Akbarian, Y Ghasemi, VN Uversky… - International journal of …, 2018 - Elsevier
Insulin, a key peptide hormone that conjointly with its receptor regulates blood glucose
levels, is used as the major means to treat diabetes. This therapeutic hormone may undergo …

Effect of fetal bovine serum or basic fibroblast growth factor on cell survival and the proliferation of neural stem cells: The influence of homocysteine treatment

DJ Petrović, D Jagečić, J Krasić, N Sinčić… - International Journal of …, 2023 - mdpi.com
In vitro cell culture is a routinely used method which is also applied for in vitro modeling of
various neurological diseases. On the other hand, media used for cell culture are often not …