Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …

The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Metabolic dysfunction–associated steatohepatitis (MASH) is a severe form of liver disease
that poses a global health threat because of its potential to progress to advanced fibrosis …

Drug evaluation has always been an important area of research in the pharmaceutical
industry. However, animal welfare protection and other shortcomings of traditional drug …

Nonalcoholic steatohepatitis (NASH) might soon become the leading cause of end-stage
liver disease and indication for liver transplantation worldwide. Fibrosis severity is the only …

Genome-wide association studies (GWAS) have now correlated hundreds of genetic
variants with complex genetic diseases and drug efficacy. Functional characterization of …

An organ-on-a-chip is a device that combines micro-manufacturing and tissue engineering
to replicate the critical physiological environment and functions of the human organs …

Non-alcoholic fatty liver disease (NAFLD) represents a global healthcare challenge,
affecting 1 in 4 adults, and death rates are predicted to rise inexorably. The progressive form …

Organ on a chip refers to microengineered biomimetic system which reflects structural and
functional characteristics of human tissue. It involves biomaterial technology, cell biology …

New drug discovery is under growing pressure to satisfy the demand from a wide range of
domains, especially from the pharmaceutical industry and healthcare services. Assessment …