Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Biophysical cues stemming from the extracellular environment are rapidly transduced into
discernible chemical messages (mechanotransduction) that direct cellular activities–placing …

Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to
the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We …

Cell interactions with the extracellular matrix (ECM) can regulate multiple cellular activities
and the matrix itself in dynamic, bidirectional processes. One such process is local …

Background: Integrin family are known as key gears in focal adhesion for triple-negative
breast cancer (TNBC) metastasis. However, the integrin independent factor TLN1 remains …

BACKGROUND: Esophageal cancer consists of two major histologic types: esophageal
squamous cell carcinoma (ESCC), predominant globally, and esophageal adenocarcinoma …

The mechanical signals within the extracellular matrix (ECM) regulate cell growth,
proliferation and differentiation, and integrins function as the hub between the ECM and …

Talin is a ubiquitous, large focal adhesion protein that links intracellular networks with the
extracellular matrix (ECM) via its connection with the actin cytoskeleton and membrane …

Disseminated prostate cancer cells must survive in circulation for metastasis to occur.
Mechanisms by which these cells survive are not well understood. By immunohistochemistry …

Context The highly invasive properties demonstrated by head and neck squamous cell
carcinoma (HNSCC) are often associated with locoregional recurrence and lymph node …