Age-related alterations in the human blood system occur in B cells, T cells, cells of the innate
system, as well as hematopoietic stem and progenitor cells (HSPCs). Interestingly, age …

Autophagy is a crucial recycling process that is increasingly being recognized as an
important factor in cancer initiation, cancer (stem) cell maintenance as well as the …

Abstract SF3B1, SRSF2, and U2AF1 are the most frequently mutated splicing factor genes in
the myelodysplastic syndromes (MDS). We have performed a comprehensive and …

Our understanding of the genetics of acute myeloid leukemia (AML) development from
myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation …

Myelodysplastic syndrome (MDS) is clonal disorder characterized by ineffective
hematopoiesis and a tendency to evolve into acute myeloid leukemia (AML). Genetic studies …

Cancer development is a dynamic process during which the successive accumulation of
mutations results in cells with increasingly malignant characteristics. Here, we show the …

Human leukemias are liquid malignancies characterized by diffuse infiltration of the bone
marrow by transformed hematopoietic progenitors. The accessibility of tumor cells obtained …

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …

Recent studies have demonstrated that myelodysplastic syndromes (MDSs) arise from a
small population of disease-initiating hematopoietic stem cells (HSCs) that persist and …

Similar to their healthy counterpart, malignant hematopoietic stem cells in myeloid
malignancies, such as myeloproliferative neoplasms, myelodysplastic syndromes, and acute …