Chronic myeloid leukaemia (CML) can be considered as a paradigm for neoplasias that
evolve through a multi-step process. CML is also one of the best examples of a disease that …

Treatment options for chronic myeloid leukemia (CML) have changed dramatically during
the last decades. Interferon-α treatment and stem cell transplantation (SCT) clearly improved …

The arrest of differentiation is a feature of both chronic myelogenous leukemia cells in
myeloid blast crisis and myeloid precursors that ectopically express the p210BCR-ABL …

Chronic myeloid leukemia (CML) starts with the acquisition of a BCR-ABL fusion gene in a
single hematopoietic stem cell, but the time to progression is unpredictable. Although the …

Chronic myelogenous leukemia (CML) results from malignant transformation of a primitive
hematopoietic cell by the BCR/ABL oncogene. The breakpoint cluster region/ABL …

This study demonstrates in both stable and inducible BCR-ABL–expressing hematopoietic
cells a down-regulation of the major mammalian DNA repair protein DNA-PKcs by BCR …

Chronic myelogenous leukemia is a myeloproliferative disorder (MPD) that, over time,
progresses to acute leukemia. Both processes are closely associated with the t (9; 22) …

Systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cell
accumulation in various tissues. Two classes of constitutive activating c-kit mutations are …

Chronic myeloid leukemia (CML) was the first human malignancy shown to be associated
with a specific cytogenetic lesion, the Philadelphia chromosomal translocation. Forty years …

Chronic myeloid leukemia (CML) is caused by Bcr-Abl, an activated tyrosine kinase. The
amounts of Bcr-Abl mRNA and protein in cells from patients in blast crisis (BC) are higher …