Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

The retina is an immune privileged tissue, which is protected from external and internal
insults by its blood-retina barriers and immune suppressive microenvironment. Apart from …

The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

In this work we advance the hypothesis that omega-3 (ω-3) long-chain polyunsaturated fatty
acids (LCPUFAs) exhibit cytoprotective and cytotherapeutic actions contributing to a number …

Mammalian tissues contain at least two types of cannabinoid receptor, CB1 and CB2, both
coupled to G proteins. CB1 receptors are expressed mainly by neurones of the central and …

After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

The endogenous cannabinoid system is an ubiquitous lipid signalling system that appeared
early in evolution and which has important regulatory functions throughout the body in all …

The endocannabinoid system consists of endogenous cannabinoids (endocannabinoids),
the enzymes that synthesize and degrade endocannabinoids, and the receptors that …

The development of new therapeutic strategies is essential for the management of gliomas,
one of the most malignant forms of cancer. We have shown previously that the growth of the …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid …