The Tumor Necrosis Factor-alpha (TNF-α) is a pleiotropic cytokine that produces different
stimuli in various physiological and pathological conditions. TNF-α contributes importantly to …

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by
excessive production of a variety of autoantibodies, accumulation of immune complexes …

Review on B cell signaling pathways in lupus risk genes, possibly representing a unique
therapeutic opportunity. Over 50 genetic variants have been statistically associated with the …

Systemic lupus erythematosus (SLE) is a chronic autoimmune systemic disease that mainly
affects women of reproductive age. Emerging data from recent molecular studies show us …

Rationale Recent clinical and preclinical studies have demonstrated that systemic lupus
erythematosus (SLE) is associated with an increased risk for cardiovascular disease (CVD) …

Background A number of observational studies have been conducted to investigate the
association of the IL-10 gene polymorphisms with systemic lupus erythematosus (SLE) …

SLE is an autoimmune disease that is not uncommon in Malaysia. In contrast to Malays and
Indians, the Chinese seem to be most affected. SLE is characterized by deficiency of body …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with unknown
aetiology. According to the role of interleukin 10 (IL10) in SLE pathogenesis, the genetic …

Introduction Systemic lupus erythematosus (SLE) is a disorder of immune regulation where
cytokine imbalance and genetic factors are implicated in its pathogenesis. Aim of the work …

As abundant types of genetic predisposition and environmental factors seem to be
associated with the development of juvenile-onset systemic lupus erythematosus (JSLE), we …