Control of poly (A) tail length
CR Eckmann, C Rammelt… - Wiley Interdisciplinary …, 2011 - Wiley Online Library
Poly (A) tails have long been known as stable 3′ modifications of eukaryotic mRNAs,
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …
added during nuclear pre‐mRNA processing. It is now appreciated that this modification is …
Nuclear RNA surveillance: role of TRAMP in controlling exosome specificity
The advent of high‐throughput sequencing technologies has revealed that pervasive
transcription generates RNAs from nearly all regions of eukaryotic genomes. Normally …
transcription generates RNAs from nearly all regions of eukaryotic genomes. Normally …
Interaction profiling identifies the human nuclear exosome targeting complex
M Lubas, MS Christensen, MS Kristiansen… - Molecular cell, 2011 - cell.com
The RNA exosome is a conserved degradation machinery, which obtains full activity only
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …
when associated with cofactors. The most prominent activator of the yeast nuclear exosome …
Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases
V Liudkovska, A Dziembowski - Wiley Interdisciplinary Reviews …, 2021 - Wiley Online Library
Termini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all
classes of RNA species have been shown to acquire nontemplated nucleotides that are …
classes of RNA species have been shown to acquire nontemplated nucleotides that are …
Ski2-like RNA helicase structures: common themes and complex assemblies
SJ Johnson, RN Jackson - RNA biology, 2013 - Taylor & Francis
Ski2-like RNA helicases are large multidomain proteins involved in a variety of RNA
processing and degradation events. Recent structures of Mtr4, Ski2 and Brr2 provide our first …
processing and degradation events. Recent structures of Mtr4, Ski2 and Brr2 provide our first …
PAPD5, a noncanonical poly (A) polymerase with an unusual RNA-binding motif
PAPD5 is one of the seven members of the family of noncanonical poly (A) polymerases in
human cells. PAPD5 was shown to polyadenylate aberrant pre-ribosomal RNAs in vivo …
human cells. PAPD5 was shown to polyadenylate aberrant pre-ribosomal RNAs in vivo …
Polyadenylation-assisted RNA degradation processes in plants
H Lange, FM Sement, J Canaday, D Gagliardi - Trends in plant science, 2009 - cell.com
Polyadenylation is a multifunctional post-transcriptional modification that is best known for
stabilizing eukaryotic mRNAs and promoting their translation. However, the primordial role …
stabilizing eukaryotic mRNAs and promoting their translation. However, the primordial role …
New perspectives on the diversification of the RNA interference system: insights from comparative genomics and small RNA sequencing
Our understanding of the pervasive involvement of small RNAs in regulating diverse
biological processes has been greatly augmented by recent application of deep …
biological processes has been greatly augmented by recent application of deep …
Mpn1, mutated in poikiloderma with neutropenia protein 1, is a conserved 3′-to-5′ RNA exonuclease processing U6 small nuclear RNA
V Shchepachev, H Wischnewski, E Missiaglia… - Cell reports, 2012 - cell.com
Clericuzio-type poikiloderma with neutropenia (PN) is a rare genodermatosis associated
with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1 …
with mutations in the C16orf57 gene, which codes for the uncharacterized protein hMpn1 …
A conserved virus-induced cytoplasmic TRAMP-like complex recruits the exosome to target viral RNA for degradation
JM Molleston, LR Sabin, RH Moy… - Genes & …, 2016 - genesdev.cshlp.org
RNA degradation is tightly regulated to selectively target aberrant RNAs, including viral
RNA, but this regulation is incompletely understood. Through RNAi screening in Drosophila …
RNA, but this regulation is incompletely understood. Through RNAi screening in Drosophila …