Strategies to overcome cancer multidrug resistance (MDR) through targeting P-glycoprotein (ABCB1): an updated review
The emergence of multidrug resistance (MDR) in malignant tumors is one of the leading
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
threats encountered currently in many chemotherapeutic agents. The overexpression of the …
Deciphering JAK/STAT signaling pathway: A multifaceted approach to tumorigenesis, progression and therapeutic interventions
Y Wang, Z Wang, S Li, J Ma, X Dai, J Lu - International …, 2024 - Elsevier
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway,
essential for cellular communication, orchestrates a myriad of physiological and pathological …
essential for cellular communication, orchestrates a myriad of physiological and pathological …
Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2
CP Wu, SH Hsiao, YS Wu - Drug Resistance Updates, 2023 - Elsevier
The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …
Synergistic toxic mechanisms of microplastics and triclosan via multixenobiotic resistance (MXR) inhibition–mediated autophagy in the freshwater water flea Daphnia …
Since a mixed state of environmental contaminants, including microplastics (MPs), heavy
metals, pharmaceuticals, and personal care products (PPCPs), exists in aquatic ecosystems …
metals, pharmaceuticals, and personal care products (PPCPs), exists in aquatic ecosystems …
[HTML][HTML] Jiao-tai-wan and its effective component-coptisine alleviate cognitive impairment in db/db mice through the JAK2/STAT3 signaling pathway
K Nie, Y Gao, H Wang, H Su, S Chen, X Jiang, H Dong… - Phytomedicine, 2024 - Elsevier
Background Cognitive impairment (CI) is now well-accepted as a complication and
comorbidity of diabetes mellitus (DM), becoming a serious medical and social problem. Jiao …
comorbidity of diabetes mellitus (DM), becoming a serious medical and social problem. Jiao …
Terconazole, an azole antifungal drug, increases cytotoxicity in antimitotic drug-treated resistant cancer cells with substrate-specific P-gp inhibitory activity
JS Lee, Y Oh, JH Park, SY Kyung, HS Kim… - International Journal of …, 2022 - mdpi.com
Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole …
[HTML][HTML] Use of drug sensitisers to improve therapeutic index in cancer
The clinical management of malignant tumours is challenging, often leading to severe
adverse effects and death. Drug resistance (DR) antagonises the effectiveness of …
adverse effects and death. Drug resistance (DR) antagonises the effectiveness of …
Low-dose rifabutin increases cytotoxicity in antimitotic-drug-treated resistant cancer cells by exhibiting strong P-gp-inhibitory activity
JS Lee, Y Oh, HS Kim, S Yoon - International Journal of Molecular …, 2022 - mdpi.com
The cytotoxicity of various antibiotics at low doses in drug-resistant cancer cells was
evaluated. Low doses of rifabutin were found to markedly increase the cytotoxicity of various …
evaluated. Low doses of rifabutin were found to markedly increase the cytotoxicity of various …
Combination treatment using pyruvate kinase M2 inhibitors for the sensitization of high density triple-negative breast cancer cells
JS Lee, Y Oh, JS Lee, JH Park, JK Shin, JH Han… - in vivo, 2022 - iv.iiarjournals.org
Abstract Background/Aim: Few studies have examined the correlation between pyruvate
kinase M2 (PKM2) overexpression and triple-negative breast cancer (TNBC). TNBC is …
kinase M2 (PKM2) overexpression and triple-negative breast cancer (TNBC). TNBC is …
Pharmacological Strategies for Overcoming Multidrug Resistance to Chemotherapy
TA Fedotcheva, NL Shimanovsky - Pharmaceutical Chemistry Journal, 2023 - Springer
Actual mechanisms of multidrug resistance (MDR) to chemotherapy in oncology are
considered. ABC-transporters such as P-glycoprotein, BCRP protein, and MRP proteins take …
considered. ABC-transporters such as P-glycoprotein, BCRP protein, and MRP proteins take …