The neural crest (NC) is a transient, multipotent and migratory cell population that generates
an astonishingly diverse array of cell types during vertebrate development. These cells …

Embryonic mammary gland development involves the formation of mammary placodes,
invagination of flask-shaped mammary buds and development of miniature bi-layered ductal …

Hypohidrotic ectodermal dysplasia (HED) is characterized by hypotrichosis (sparseness of
scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital …

Pathogenic variants in KMT2D, which encodes lysine specific methyltransferase 2D, cause
autosomal dominant Kabuki syndrome, associated with distinctive dysmorphic features …

The stroma, which is composed of supporting cells and connective tissue, comprises a large
component of the local microenvironment of many epithelial cell types, and influences …

Abstract Background Ectodysplasin-A (EDA), a skin-specific TNF ligand, interacts with its
membrane receptor EDAR to trigger EDA signaling in skin appendage formation. Gene …

Ectodysplasin A receptor (EDAR) is a death receptor in the Tumour Necrosis Factor
Receptor (TNFR) superfamily with roles in the development of hair follicles, teeth and …

Ectodysplasin (Eda) is the most studied tumor necrosis ligand in the field of developmental
biology. In all vertebrates studied so far, inactivating germline mutations in Eda lead to the …

Hintergrund Obwohl Mutationen im X-chromosomalen Gen EDA, die der häufigsten Form
ektodermaler Dysplasie (XLHED) zugrunde liegen, nur bei betroffenen Männern zum …

Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure
of development of the tissues derived from the embryonic ectoderm. ED is often associated …