Background The use of cannabis, or marijuana, for medicinal purposes is deeply rooted
though history, dating back to ancient times. It once held a prominent position in the history …

Dopamine (DA), serotonin (5-hydroxytryptamine, 5-HT), and endocannabinoids (ECs) are
key neuromodulators involved in many aspects of motivated behavior, including reward …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

Preclinical and clinical studies show that cannabis modulates mood and possesses
antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

The pathophysiological neural mechanism underlying the depressogenic and anxiogenic
effects of chronic adolescent cannabinoid use may be linked to perturbations in …

Fatty acid binding proteins (FABPs), in particular FABP5 and FABP7, have recently been
identified by us as intracellular transporters for the endocannabinoid anandamide (AEA) …

Since the discovery of endocannabinoids and their receptors, two major members of the
endocannabinoid family, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been …

The cannabinoid CB1 receptors and their endogenous agonists, endocannabinoids (eCBs),
are ubiquitously distributed throughout the central nervous system (CNS), where they play a …

Serotonin (5-HT) neurons located in the raphe nuclei modulate a wide range of behaviors by
means of an expansive innervation pattern. In turn, the raphe receives a vast array of …