There is great need for stand-alone luminescence-based chemosensors that exemplify
selectivity, sensitivity, and applicability and that overcome the challenges that arise from …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Background Incentives to promote drinking (“happy hour”) can encourage faster rates of
alcohol consumption, especially in women. Sex differences in drinking dynamics may …

Long-term alcohol use leads to persistent cognitive deficits that may be associated with
maladaptive changes in the neurocircuitry that mediates executive functions. Impairments …

After decades of uncertainties and drawbacks, the study on the role and significance of
acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the …

Abnormal consumption of ethanol, the ingredient responsible for alcoholic drinks' addictive
liability, causes millions of deaths yearly. Ethanol's addictive potential is triggered through …

Background Life expectancy is greatly reduced in individuals presenting alcohol use
disorders and chronic smoking. Literature studies suggest that common mechanisms may …

Background A number of studies have shown that acetaldehyde synthesized in the brain is
necessary to induce ethanol (EtOH) reinforcement in naïve animals (acquisition phase) …

Background Early onset drinking is associated with later heavy drinking and related
consequences. Early drinking onset and binge drinking are also independently associated …

Despite the role of aldehyde dehydrogenase 2 (ALDH2) in the detoxification of endogenous
aldehydes, the defective polymorphism (rs671), which is highly prevalent among East …