Targeting cannabinoid receptors: current status and prospects of natural products
D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …
critical role in numerous human physiological and pathological conditions. Thus …
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
G Donvito, SR Nass, JL Wilkerson, ZA Curry… - …, 2018 - nature.com
A great need exists for the development of new medications to treat pain resulting from
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
various disease states and types of injury. Given that the endogenous cannabinoid (that is …
β-Caryophyllene, a Natural Sesquiterpene, Attenuates Neuropathic Pain and Depressive-Like Behavior in Experimental Diabetic Mice
DS Aguilar-Avila, ME Flores-Soto… - Journal of medicinal …, 2019 - liebertpub.com
Neuropathic pain (NP) is associated with chronic hyperglycemia and emotional disorders
such as depression in diabetic patients, complicating the course of treatment. Drugs …
such as depression in diabetic patients, complicating the course of treatment. Drugs …
Targeting peripherally restricted cannabinoid receptor 1, cannabinoid receptor 2, and endocannabinoid-degrading enzymes for the treatment of neuropathic pain …
MZ Hossain, H Ando, S Unno, J Kitagawa - International journal of …, 2020 - mdpi.com
Neuropathic pain conditions including neuropathic orofacial pain (NOP) are difficult to treat.
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
Contemporary therapeutic agents for neuropathic pain are often ineffective in relieving pain …
The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and …
O Pol - Medicinal Research Reviews, 2021 - Wiley Online Library
Chronic pain and its associated comorbidities are difficult to treat, even when the most
potent analgesic compounds are used. Thus, research on new strategies to effectively …
potent analgesic compounds are used. Thus, research on new strategies to effectively …
Suppressing PKC-dependent membrane P2X3 receptor upregulation in dorsal root ganglia mediated electroacupuncture analgesia in rat painful diabetic neuropathy
Y Zhou, X Ying, X He, SY Shou, JJ Wei, Z Tai… - Purinergic …, 2018 - Springer
Painful diabetic neuropathy (PDN) is a common and troublesome diabetes complication.
Protein kinase C (PKC)-mediated dorsal root ganglia (DRG) P2X3 receptor upregulation is …
Protein kinase C (PKC)-mediated dorsal root ganglia (DRG) P2X3 receptor upregulation is …
Novel toxicodynamic model of subcutaneous envenomation to characterize snake venom coagulopathies and assess the efficacy of site-directed inorganic …
VG Nielsen - International Journal of Molecular Sciences, 2023 - mdpi.com
Venomous snake bite adversely affects millions of people yearly, but few animal models
allow for the determination of toxicodynamic timelines with hemotoxic venoms to …
allow for the determination of toxicodynamic timelines with hemotoxic venoms to …
Levo-corydalmine attenuates vincristine-induced neuropathic pain in mice by upregulating the Nrf2/HO-1/CO pathway to inhibit connexin 43 expression
L Zhou, L Ao, Y Yan, C Li, W Li, A Ye, J Liu, Y Hu… - …, 2020 - Springer
Antimicrotubulin chemotherapeutic agents, including plant-derived vincaalkaloids such as
vincristine, can cause peripheral neuropathic pain. Exogenously activated heme oxygenase …
vincristine, can cause peripheral neuropathic pain. Exogenously activated heme oxygenase …
An overview of the potential therapeutic applications of CO‐releasing molecules
A Ismailova, D Kuter, DS Bohle… - Bioinorganic Chemistry …, 2018 - Wiley Online Library
Carbon monoxide (CO) has long been known as the “silent killer” owing to its ability to form
carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an …
carboxyhemoglobin—the main cause of CO poisoning in humans. Its role as an …
The anxiolytic and antidepressant effects of diallyl disulfide and GYY4137 in animals with chronic neuropathic pain
X Bai, G Batallé, O Pol - Antioxidants, 2021 - mdpi.com
When neuropathic pain is maintained long term, it can also lead to the development of
emotional disorders that are even more intense than pain perception and difficult to treat …
emotional disorders that are even more intense than pain perception and difficult to treat …