Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …

Obesity is a serious medical condition worldwide, which needs new approaches and
recognized international consensus in treating diseases leading to morbidity. The aim of this …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains …

Abstract The Bromodomain and Extra-terminal (BET) family of proteins were first recognized
as important epigenetic regulators in inflammatory processes; however, there is increasing …

Multiple cell-signalling pathways converge on chromatin to induce gene expression
programmes. The inducible transcriptional programmes that are established as a result of …

Diabetic kidney disease is one of the fastest growing causes of death worldwide. Epigenetic
regulators control gene expression and are potential therapeutic targets. There is functional …

Therapeutic strategies aiming to leverage anti-tumor immunity are being intensively
investigated as they show promising results in cancer therapy. The PD-1/PD-L1 pathway …

Inhibitors of bromodomain and extraterminal domain (BET) proteins are possible anti-severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) prophylactics as they …

Recently, selective inhibition of BET BD2 is emerging as a promising strategy for drug
discovery. Despite significant progress in this area, systematic studies of selective BET BD2 …