Retinitis pigmentosa (RP) is a heterogeneous group of hereditary diseases characterized by
progressive degeneration of retinal photoreceptors leading to progressive visual decline. It …

Retinitis pigmentosa (RP) is a group of genetic disorders resulting in inherited blindness due
to the degeneration of rod and cone photoreceptors. The various mechanisms underlying …

A high-fat diet (HFD) can induce hyperglycemia and metabolic syndromes that, in turn, can
trigger visual impairment. To evaluate the acute effects of HFD feeding on retinal …

The retina is particularly vulnerable to genetic and environmental alterations that generate
oxidative stress and cause cellular damage in photoreceptors and other retinal neurons …

Nucleocytoplasmic transport comprises the multistep assembly, transport, and disassembly
of protein and RNA cargoes entering and exiting nuclear pores. Accruing evidence supports …

Multiple gene mutations have been associated with inherited retinal dystrophies (IRDs).
Despite the spectrum of phenotypes caused by the distinct mutations, IRDs display common …

Purpose: Strategies for neuroprotection are the main targets of glaucoma research. The
neuroprotective properties of SRT2104 administration have been proven in central nervous …

The gut microbiome is known to influence the pathogenesis and progression of
neurodegenerative diseases. However, there has been relatively little focus upon the …

Purpose: To test the hypothesis that changing energy needs alter mitochondria distribution
within the rod inner segment ellipsoid. Methods: In mice with relatively smaller (C57BL/6J …

We investigate glial cell activation and oxidative stress induced by taurine deficiency
secondary to β-alanine administration and light exposure. Two months old Sprague-Dawley …