Background: Thiazole is a good pharmacophore nucleus due to its various pharmaceutical
applications. Its derivatives have a wide range of biological activities such as antioxidant …

Diabetes mellitus is a medical condition characterized by the body's loss of control over
blood sugar. The frequency of diagnosed cases and consequential increases in medical …

Phosphorylation is an essential process in biological events and is considered critical for
biological functions. In tissues, protein phosphorylation mainly occurs on tyrosine (Tyr) …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Diabetes mellitus is a metabolic disease characterized by high blood glucose levels and
usually associated with several chronic pathologies. Aldose reductase and protein tyrosine …

In the current study, two series of novel thiazolidin-4-one benzenesulfonamide arylidene
hybrids 9a-l and 10a-f were designed, synthesized and tested in vitro for their PPARɣ …

Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such,
tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential …

Protein tyrosine phosphatases (PTPs) superfamily catalyzes tyrosine de‐phosphorylation
which affects a myriad of cellular processes. Imbalance in signal pathways mediated by …

Background Ginger is widely used in traditional food and folk medicine. It was known to
contain monoterpenoids, sesquiterpenoids, phenolic compounds and its derivatives as well …

Diabetes mellitus is the most serious and prevalent metabolic disorders worldwide,
complications of which can decrease significantly the quality of life and contribute to …