Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

This review focuses on the role of prenatal hypoxia in the development of brain functions in
the postnatal period and subsequent increased risk of neurodegenerative disorders in later …

Abstract Aims Cardiac microRNA-132-3p (miR-132) levels are increased in patients with
heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a …

Neural stem cells residing in the hippocampal neurogenic niche sustain lifelong
neurogenesis in the adult brain. Adult hippocampal neurogenesis (AHN) is functionally …

Abstract Alzheimer's disease (AD), the most frequent cause of dementia, is escalating as a
global epidemic, and so far, there is neither cure nor treatment to alter its progression. The …

Background Minimally invasive specific biomarkers of neurodegenerative diseases (NDs)
would facilitate patient selection and disease progression monitoring. We describe the …

Alzheimer's disease (AD) is a multifaceted, advancing neurodegenerative illness that is
responsible for most cases of neurological impairment and dementia in the aged population …

Synaptic dysfunction and abnormal processing of amyloid precursor protein (APP) are early
pathological features in Alzheimer's disease (AD). Recently, non-coding RNAs such as …

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …

MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …