Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways
Bone-related diseases are major contributors to morbidity and mortality in elderly people
and the current treatments result in insufficient healing and several complications. One of the …
and the current treatments result in insufficient healing and several complications. One of the …
Materials-based nanotherapeutics for injured and diseased bone
Severe injuries and diseases of bone tissue caused by congenital disorder, extrinsic trauma,
infection, and osteosarcoma resection face significant challenges for complete recovery. The …
infection, and osteosarcoma resection face significant challenges for complete recovery. The …
Long-term induction of endogenous BMPs growth factor from antibacterial dual network hydrogels for fast large bone defect repair
Q Yao, Y Liu, Y Pan, Y Li, L Xu, Y Zhong… - Journal of Colloid and …, 2022 - Elsevier
Osteoinductive, osteoconductive, and antibacterial properties of bone repair materials play
important roles in regulating the successful bone regeneration. In the present work, we …
important roles in regulating the successful bone regeneration. In the present work, we …
Trb3 controls mesenchymal stem cell lineage fate and enhances bone regeneration by scaffold-mediated local gene delivery
Aberrant lineage commitment of mesenchymal stem cells (MSCs) in marrow contributes to
abnormal bone formation due to reduced osteogenic and increased adipogenic potency …
abnormal bone formation due to reduced osteogenic and increased adipogenic potency …
Design of hydrogels to stabilize and enhance bone morphogenetic protein activity by heparin mimetics
Although bone morphogenetic protein-2 (BMP-2) is known to be the most potent stimulator
available for bone formation, a major barrier to widespread clinical use is its inherent …
available for bone formation, a major barrier to widespread clinical use is its inherent …
Rational design of hydrogels to enhance osteogenic potential
Bone tissue engineering (BTE) encompasses the field of biomaterials, cells, and bioactive
molecules to successfully guide the growth and repair of bone tissue. Current BTE strategies …
molecules to successfully guide the growth and repair of bone tissue. Current BTE strategies …
Bioactive scaffolds as a promising alternative for enhancing critical-size bone defect regeneration in the craniomaxillofacial region
SA Bello, J Cruz-Lebrón… - ACS Applied Bio …, 2023 - ACS Publications
Reconstruction of critical-size bone defects (CSDs) in the craniomaxillofacial (CMF) region
remains challenging. Scaffold-based bone-engineered constructs have been proposed as …
remains challenging. Scaffold-based bone-engineered constructs have been proposed as …
Complementary modulation of BMP signaling improves bone healing efficiency
The bone morphogenetic protein (BMP) signaling pathway plays a crucial role in bone
development and regeneration. While BMP-2 is widely used as an alternative to autograft, its …
development and regeneration. While BMP-2 is widely used as an alternative to autograft, its …
Small molecule-mediated regenerative engineering for craniofacial and dentoalveolar bone
J Mitchell, KWH Lo - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
The comprehensive reconstruction of extensive craniofacial and dentoalveolar defects
remains a major clinical challenge to this day, especially in complex medical cases involving …
remains a major clinical challenge to this day, especially in complex medical cases involving …
Effects on bone regeneration of single-dose treatment with osteogenic small molecules
KWH Lo - Drug Discovery Today, 2022 - Elsevier
Highlights•Small molecules have been proposed as alternatives to regenerate bone
tissue.•Small molecule drug dose can often be reduced while still achieving effective …
tissue.•Small molecule drug dose can often be reduced while still achieving effective …