[HTML][HTML] Heparin binding proteins as therapeutic target: an historical account and current trends

G Ghiselli - Medicines, 2019 - mdpi.com
The polyanionic nature and the ability to interact with proteins with different affinities are
properties of sulfated glycosaminoglycans (GAGs) that determine their biological function. In …

Synthetic xylosides: probing the glycosaminoglycan biosynthetic machinery for biomedical applications

JS Chua, B Kuberan - Accounts of Chemical Research, 2017 - ACS Publications
Conspectus Glycosaminoglycans (GAGs) are polysaccharides ubiquitously found on cell
surfaces and in the extracellular matrix (ECM). They regulate numerous cellular signaling …

Blueberry metabolites restore cell surface glycosaminoglycans and attenuate endothelial inflammation in diabetic human aortic endothelial cells

BR Cutler, S Gholami, JS Chua, B Kuberan… - International journal of …, 2018 - Elsevier
Background Glycosaminoglycan (GAG), a major component of the endothelial glycocalyx, is
severely perturbed in diabetic vasculature leading to endothelial inflammation and vascular …

[HTML][HTML] Angiogenic potential in biological hydrogels

MV Giraudo, D Di Francesco, MC Catoira, D Cotella… - Biomedicines, 2020 - mdpi.com
Hydrogels are three-dimensional (3D) materials able to absorb and retain water in large
amounts while maintaining their structural stability. Due to their considerable …

[HTML][HTML] Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI—Evidence from in vitro and in vivo models

E Entchev, I Jantzen, P Masson, S Bocart, B Bournique… - PloS one, 2020 - journals.plos.org
Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by
enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG). Pathological …

Fibrinogen-based cell and spheroid sheets manipulating and delivery for mouse hindlimb ischemia

J Lim, MS Lee, J Jeon, HS Yang - Biofabrication, 2023 - iopscience.iop.org
In this research, we introduced a novel strategy for fabricating cell sheets (CSs) prepared by
simply adding a fibrinogen solution to growth medium without using any synthetic polymers …

Methods for Assessing the Effects of Xylosides on Angiogenesis

JS Chua, G Muruganandam, Y Saijoh… - … : Methods and Protocols, 2022 - Springer
Xylosides are small synthetic molecules consisting of a xylose molecule attached to an
aglycone group and serve as primers in the assembly of core protein free …