Lipid droplets (LDs) are dynamic, cytosolic lipid‐storage organelles found in nearly all cell
types. Too many or too few LDs during excess or deficient fat storage lead to many different …

The tumor stroma is no longer seen solely as physical support for mutated epithelial cells but
as an important modulator and even a driver of tumorigenicity. Within the tumor stromal …

Objective Accumulation of myofibroblasts in fibrotic skin is a hallmark of systemic sclerosis
(SSc; scleroderma), but the origins of these cells remain unknown. Because loss of …

Background Cancer cachexia is a progressive and multi-factorial metabolic syndrome
characterized by loss of adipose tissue and skeletal muscle. White adipose tissue (WAT) …

White adipose tissue and skeletal muscle are the largest organs in the body and both are
composed of distinct cell types. The signature cell of adipose tissue is the adipocyte while …

Although high mammographic density is considered one of the strongest risk factors for
invasive breast cancer, the genes involved in modulating this clinical feature are unknown …

Pathologic diabetic wound healing is caused by sequential and progressive deterioration of
hemostasis, inflammation, proliferation, and resolution/remodeling. Cellular senescence …

In this review we introduce the concept of the tumor macroenvironment and explore it in the
context of metabolism. Tumor cells interact with the tumor microenvironment including …

The majority of cancer patients experience wasting characterized by muscle loss with or
without fat loss. In human and animal models of cancer, body composition assessment and …

Obesity is a complex disease caused by the interaction of a myriad of genetic, dietary,
lifestyle and environmental factors, which favors a chronic positive energy balance, leading …