Diffuse large B-cell lymphoma (DLBCL), the most frequent subtype of lymphoid malignancy,
remains a significant clinical challenge, as∼ 30% of patients are not cured. Over the past …

Germinal centers (GCs) were described more than 125 years ago as compartments within
secondary lymphoid organs that contained mitotic cells. Since then, it has become clear that …

Somatic mutations in CREBBP occur frequently in B-cell lymphoma. Here, we show that loss
of CREBBP facilitates the development of germinal center (GC)–derived lymphomas in mice …

Although single-cell and spatial sequencing methods enable simultaneous measurement of
more than one biological modality, no technology can capture all modalities within the same …

Sequence preferences of DNA binding proteins are a primary mechanism by which cells
interpret the genome. Despite the central importance of these proteins in physiology …

Antibody class switching occurs in mature B cells in response to antigen stimulation and
costimulatory signals. It occurs by a unique type of intrachromosomal deletional …

One of the unusual features of germinal center (GC) B cells is that they manifest many
hallmarks of cancer cells. Accordingly, most B‐cell neoplasms originate from the GC …

BCL6 is a transcriptional repressor required in mature B cells during the germinal center
(GC) reaction. Multiple mechanisms act coordinately to timely modulate BCL6 expression at …

Over the past several years, studies on normal and malignant B cells have provided new
insights into the unique physiology of the germinal centre (GC). In particular, advances in …

Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody
affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification …