Triggering of tumour cell apoptosis is the foundation of many cancer therapies. Death
receptors of the tumour necrosis factor (TNF) superfamily have been largely characterized …

Nanoparticle drug delivery systems have proved anti-tumor effects; however, they are not
widely used in tumor therapy due to insufficient ability to target specific sites, multidrug …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), also known as Apo-
2 ligand (Apo2L), is a member of the TNF cytokine superfamily. By cross-linking TRAIL …

Malignancy is a major public health problem and among the leading lethal diseases
worldwide. Although the current tumor treatment methods have therapeutic effect to a certain …

Artificial endonucleases consisting of a Fok I cleavage domain tethered to engineered zinc-
finger DNA-binding proteins have proven useful for stimulating homologous recombination …

Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …

How the thermodynamic stability effects of protein mutations (ΔΔG) are distributed is a
fundamental property related to the architecture, tolerance to mutations (mutational …

Malignant melanoma is considered the most aggressive skin carcinoma with invasive
growth patterns. Triptolide (TPL) possesses various biological and pharmacological …

Interaction specificity is a required feature of biological networks and a necessary
characteristic of protein or small-molecule reagents and therapeutics. The ability to alter or …

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapy is currently
evaluated in clinical studies as a tumor cell selective pro-apoptotic approach. However …