The balance between immune effector cells and immunosuppressive cells and how this
regulates the tumor microenvironment has been well described. A significant contribution of …

Unmasking the subtleties of the immune system requires both a comprehensive knowledge
base and the ability to interrogate that system with intimate sensitivity. That task, to a …

Most spatial transcriptomics technologies are limited by their resolution, with spot sizes
larger than that of a single cell. Although joint analysis with single-cell RNA sequencing can …

B cells are capable of a wide range of effector functions including antibody secretion,
antigen presentation, cytokine production, and generation of immunological memory. A …

A key feature of the adaptive immune system is the generation of memory B and T cells and
long-lived plasma cells, providing protective immunity against recurring infectious agents …

Immune cells were traditionally considered as major pro-inflammatory contributors. Recent
advances in molecular immunology prove that immune cell lineages are composed of …

Autoantibodies are secreted by plasma cells and have an essential role in driving the renal
manifestations of autoimmune diseases such as systemic lupus erythematosus and …

Background/Aims: Impaired wound healing is considered to be one of the most serious
complications associated with diabetes as it significantly increases the susceptibility of …

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria
for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology …

Infection with the helminth Schistosoma (S.) mansoni drives the development of interleukin
(IL)-10-producing regulatory B (Breg) cells in mice and man, which have the capacity to …