Bacterial biofilms are associated with a wide range of infections, from those related to
exogenous devices, such as catheters or prosthetic joints, to chronic tissue infections such …

Biofilms are organized bacterial communities embedded in an extracellular polymeric matrix
attached to living or abiotic surfaces. The development of biofilms is currently recognized as …

Chronic infection with the bacterial pathogen Pseudomonas aeruginosa often leads to
coexistence of heterogeneous populations carrying diverse mutations. In particular, loss-of …

Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …

Cystic fibrosis (CF) is a genetic disease with mutational changes leading to profound
dysbiosis, both pulmonary and intestinal, from a very young age. This dysbiosis plays an …

The efficacy of antibiotic treatments targeting polymicrobial communities is not well predicted
by conventional in vitro susceptibility testing based on determining minimum inhibitory …

Cystic fibrosis (CF) is a genetic disease mainly manifested in the respiratory tract.
Pseudomonas aeruginosa (P. aeruginosa) is the most common pathogen identified in …

Biofilm-associated infections are difficult to treat and eradicate because of their increased
antimicrobial tolerance. In vitro biofilm models have enabled the high throughput testing of …

Persistent infections require bacteria to evolve from their naïve colonization state by
optimizing fitness in the host via simultaneous adaptation of multiple traits, which can …

The minimal inhibitory concentration (MIC) assay uses agar or broth dilution methods to
measure, under defined test conditions, the lowest effective concentration of an antimicrobial …