Mucosal and cutaneous human papillomavirus infections and cancer biology

T Gheit - Frontiers in Oncology, 2019 - frontiersin.org
Papillomaviridae is a family of small non-enveloped icosahedral viruses with double-
stranded circular DNA. More than 200 different human papillomaviruses (HPVs) have been …

APOBEC: A molecular driver in cervical cancer pathogenesis

S Revathidevi, AK Murugan, H Nakaoka, I Inoue… - Cancer letters, 2021 - Elsevier
Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

HPV16 and HPV18 genome structure, expression, and post-transcriptional regulation

L Yu, V Majerciak, ZM Zheng - International journal of molecular sciences, 2022 - mdpi.com
Human papillomaviruses (HPV) are a group of small non-enveloped DNA viruses whose
infection causes benign tumors or cancers. HPV16 and HPV18, the two most common high …

High-risk human papillomaviral oncogenes E6 and E7 target key cellular pathways to achieve oncogenesis

NSL Yeo-Teh, Y Ito, S Jha - International journal of molecular sciences, 2018 - mdpi.com
Infection with high-risk human papillomavirus (HPV) has been linked to several human
cancers, the most prominent of which is cervical cancer. The integration of the viral genome …

Footprint of the host restriction factors APOBEC3 on the genome of human viruses

F Poulain, N Lejeune, K Willemart, NA Gillet - PloS pathogens, 2020 - journals.plos.org
APOBEC3 enzymes are innate immune effectors that introduce mutations into viral
genomes. These enzymes are cytidine deaminases which transform cytosine into uracil …

Human papillomavirus and the landscape of secondary genetic alterations in oral cancers

ML Gillison, K Akagi, W Xiao, B Jiang… - Genome …, 2019 - genome.cshlp.org
Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral
squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify …

Oncogenic viruses as entropic drivers of cancer evolution

I Tempera, PM Lieberman - Frontiers in virology, 2021 - frontiersin.org
Viral infection is an indisputable causal factor for nearly 17% of all human cancers.
However, the diversity and complexity of oncogenic mechanisms raises new questions as to …

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

AM Green, MD Weitzman - DNA repair, 2019 - Elsevier
The APOBEC3 family of cytosine deaminases are part of the innate immune response to
viral infection, but also have the capacity to damage cellular DNA. Detection of mutational …

APOBEC3: friend or foe in human papillomavirus infection and oncogenesis?

CJ Warren, ML Santiago, D Pyeon - Annual review of virology, 2022 - annualreviews.org
Human papillomavirus (HPV) infection is a causative agent of multiple human cancers,
including cervical and head and neck cancers. In these HPV-positive tumors, somatic …

Human papillomavirus E7 oncoprotein targets RNF168 to hijack the host DNA damage response

J Sitz, SA Blanchet, SF Gameiro… - Proceedings of the …, 2019 - National Acad Sciences
High-risk human papillomaviruses (HR-HPVs) promote cervical cancer as well as a subset
of anogenital and head and neck cancers. Due to their limited coding capacity, HPVs hijack …