The eukaryotic pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania are
responsible for debilitating diseases that affect millions of people worldwide. The numbers of …

The modification of proteins by the addition of ubiquitin and other ubiquitin-like proteins
(UBLs) is involved in a wide range of cellular processes including cell cycle progression, the …

Neddylation is a type of posttranslational modification known to regulate a wide range of
cellular processes by covalently conjugating the ubiquitin-like protein Nedd8 to target …

Understanding how the protozoan protein degradation pathway is regulated could uncover
new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved …

Post-translational modifications such as ubiquitination are important for orchestrating the
cellular transformations that occur as the Leishmania parasite differentiates between its …

Plasmodium parasites are the causative agents of malaria, a disease with wide public health
repercussions. Increasing drug resistance and the absence of a vaccine make finding new …

Highlights•Ubiquitination and ubiquitin-like modification regulates trypanosomatid
differentiation.•Inventories of ubiquitination system components compiled for …

Cullins (CULs) are a core component of cullin-RING E3 ubiquitin ligases (CRLs), which
regulate the degradation, function, and subcellular trafficking of proteins. CULs are post …

Post-translational protein regulation allows for fine-tuning of cellular functions and involves a
wide range of modifications, including ubiquitin and ubiquitin-like modifiers (Ubls). The …

Histone modification plays an important role in various biological processes, including gene
expression regulation. Bromodomain, as one of histone readers, recognizes specifically the …