CK2 (casein kinase 2) is a serine/threonine protein kinase that is ubiquitous in eukaryotic
cells and plays important roles in a variety of cellular functions, including cell growth …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), shows significant affinity toward
the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer's …

The tight junction protein claudin-2 is upregulated in disease. Although many studies have
linked intestinal barrier loss to local and systemic disease, these have relied on …

Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) play a large variety of cellular functions and are involved in several diseases …

Sixteen flavonoids and related compounds have been tested for their ability to inhibit three
acidophilic Ser/Thr protein kinases: the Golgi apparatus casein kinase (G-CK) recently …

5-(3-Chlorophenylamino) benzo [c][2, 6] naphthyridine-8-carboxylic acid (CX-4945), the first
clinical stage inhibitor of protein kinase CK2 for the treatment of cancer, is representative of …

The casein kinase 2 (CK2) protein kinase is a pro-survival kinase and therapeutic target in
treatment of various human cancers. CK2 overexpression has been demonstrated in …

Triple negative breast cancer (TNBC) remains challenging because of heterogeneous
responses to chemotherapy. Incomplete response is associated with a greater risk of …

In this article we describe the preclinical characterization of 5-(3-chlorophenylamino) benzo
[c][2, 6] naphthyridine-8-carboxylic acid (CX-4945), the first orally available small molecule …