Many human birth defects and neurodevelopmental disorders are caused by loss-of-function
mutations in a single copy of transcription factor (TF) and chromatin regulator genes …

Our understanding of gene regulation in plants is constrained by our limited knowledge of
plant cis-regulatory DNA and its dynamics. We mapped DNase I hypersensitive sites (DHSs) …

Gene-gene interactions are crucial to the control of sub-cellular processes but our
understanding of their stochastic dynamics is hindered by the lack of simulation methods …

Plant architecture consists of repeating units called phytomers, each containing an
internode, leaf and axillary meristem. The formation of boundaries within the phytomer is …

The life cycle of bacteriophage lambda serves as a simplified paradigm for cell-fate
decisions. The ongoing quantitative, high-resolution experimental investigation of this life …

Approximately 98% of mammalian DNA is noncoding, yet we understand relatively little
about the function of this enigmatic portion of the genome. The cis-regulatory elements that …

Chromodomain helicase DNA binding protein 2 (Chd2) is a chromatin remodeller implicated
in neurological disease. Here we show that Chaserr, a highly conserved long noncoding …

Bistable autoactivation has been proposed as a mechanism for cells to adopt binary fates
during embryonic development. However, it is unclear whether the autoactivating modules …

Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …

Multiple division cycles without growth are a characteristic feature of early embryogenesis.
The female germline loads proteins and RNAs into oocytes to support these divisions, which …