Two decades ago, the sequence of the first human genome was published. Since then,
advances in genome technologies have resulted in whole-genome sequencing and …

The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Next generation sequencing (NGS) technology has revolutionized genomic and genetic
research. The pace of change in this area is rapid with three major new sequencing …

Genotype imputation is a statistical technique that is often used to increase the power and
resolution of genetic association studies. Imputation methods work by using haplotype …

A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

The reduced costs of sequencing have led to whole-genome sequences for a large number
of microorganisms, enabling the application of microbial genome-wide association studies …

It has been 100 years since the first report of sickle haemoglobin (HbS). More than 50 years
ago, it was suggested that the gene responsible for this disorder could reach high …

Recent genome-wide studies have reported novel associations between common
polymorphisms and susceptibility to many major infectious diseases in humans. In parallel …

The high mortality and widespread impact of malaria have resulted in this disease being the
strongest evolutionary selective force in recent human history, and genes that confer …

We report a genome-wide association (GWA) study of severe malaria in The Gambia. The
initial GWA scan included 2,500 children genotyped on the Affymetrix 500K GeneChip, and …