Discovery and validation of circulating microRNAs as biomarkers for epileptogenesis after experimental traumatic brain injury–the EPITARGET cohort

M Heiskanen, S Das Gupta, JD Mills… - International journal of …, 2023 - mdpi.com
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies.
The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to …

Disease-modifying effect of atipamezole in a model of post-traumatic epilepsy

J Nissinen, P Andrade, T Natunen, M Hiltunen, T Malm… - Epilepsy research, 2017 - Elsevier
Abstract Treatment of TBI remains a major unmet medical need, with 2.5 million new cases
of traumatic brain injury (TBI) each year in Europe and 1.5 million in the USA. This single …

Acute non-convulsive status epilepticus after experimental traumatic brain injury in rats

P Andrade, I Banuelos-Cabrera… - Journal of …, 2019 - liebertpub.com
Severe traumatic brain injury (TBI) induces seizures or status epilepticus (SE) in 20–30% of
patients during the acute phase. We hypothesized that severe TBI induced with lateral fluid …

Plasma Neurofilament Light Chain (NF-L) is a prognostic biomarker for cortical damage evolution but not for cognitive impairment or Epileptogenesis following …

M Heiskanen, O Jääskeläinen, E Manninen… - International Journal of …, 2022 - mdpi.com
Plasma neurofilament light chain (NF-L) levels were assessed as a diagnostic biomarker for
traumatic brain injury (TBI) and as a prognostic biomarker for somatomotor recovery …

Treatment of status epilepticus after traumatic brain injury using an antiseizure drug combined with a tissue recovery enhancer revealed by systems biology

N Kajevu, A Lipponen, P Andrade, I Bañuelos… - International Journal of …, 2023 - mdpi.com
We tested a hypothesis that in silico-discovered compounds targeting traumatic brain injury
(TBI)-induced transcriptomics dysregulations will mitigate TBI-induced molecular pathology …

Seizure susceptibility and sleep disturbance as biomarkers of epileptogenesis after experimental TBI

P Andrade, L Lara-Valderrábano, E Manninen… - Biomedicines, 2022 - mdpi.com
Objectives: We investigated whether seizure susceptibility increases over weeks–months
after experimental traumatic brain injury (TBI), and whether seizure susceptibility in rats …

[HTML][HTML] Brain abscess–A rare confounding factor for diagnosis of post-traumatic epilepsy after lateral fluid-percussion injury

J Kyyriäinen, P Andrade, XE Ndode-Ekane… - Epilepsy Research, 2024 - Elsevier
Objective To assess the prevalence of brain abscesses as a confounding factor for the
diagnosis of post-traumatic epilepsy (PTE) in a rat model of lateral fluid-percussion-induced …

Dorsolateral prefrontal neurons mediate subjective decisions and their variation in humans

M Jamali, B Grannan, K Haroush, ZB Moses… - Nature …, 2019 - nature.com
Subjective decisions play a vital role in human behavior because, while often grounded in
fact, they are inherently based on personal beliefs that can vary broadly within and between …

MRI-Guided Electrode Implantation for Chronic Intracerebral Recordings in a Rat Model of Post− Traumatic Epilepsy—Challenges and Gains

XE Ndode-Ekane, R Immonen, E Hämäläinen… - Biomedicines, 2022 - mdpi.com
Brain atrophy induced by traumatic brain injury (TBI) progresses in parallel with
epileptogenesis over time, and thus accurate placement of intracerebral electrodes to …

Detection of hyperexcitability by functional magnetic resonance imaging after experimental traumatic brain injury

JK Huttunen, AM Airaksinen, C Barba… - Journal of …, 2018 - liebertpub.com
Diagnosis of ongoing epileptogenesis and associated hyperexcitability after brain injury is a
major challenge. Given that increased neuronal activity in the brain triggers a blood …