The antitumorigenic roles of BRCA1–BARD1 in DNA repair and replication
M Tarsounas, P Sung - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …
double-strand break (DSB) repair by homologous recombination and protects DNA …
The genetic changes of Wilms tumour
TD Treger, T Chowdhury, K Pritchard-Jones… - Nature Reviews …, 2019 - nature.com
Wilms tumour is the most common renal malignancy of childhood. The disease is curable in
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …
the majority of cases, albeit at considerable cost in terms of late treatment-related effects in …
[HTML][HTML] BARD1 mystery: tumor suppressors are cancer susceptibility genes
The full-length BRCA1-associated RING domain 1 (BARD1) gene encodes a 777-aa
protein. BARD1 displays a dual role in cancer development and progression as it acts as a …
protein. BARD1 displays a dual role in cancer development and progression as it acts as a …
[HTML][HTML] Genetic predisposition to solid pediatric cancers
M Capasso, A Montella, M Tirelli, T Maiorino… - Frontiers in …, 2020 - frontiersin.org
Progresses over the past years have extensively improved our capacity to use genome-
scale analyses—including high-density genotyping and exome and genome sequencing …
scale analyses—including high-density genotyping and exome and genome sequencing …
17q gain in neuroblastoma: A review of clinical and biological implications
V Mlakar, I Dupanloup, F Gonzales… - Cancers, 2024 - mdpi.com
Simple Summary Neuroblastoma (NB) is the most frequent solid extracranial tumor in
children and the most frequently diagnosed cancer during infancy. A genetic modification, a …
children and the most frequently diagnosed cancer during infancy. A genetic modification, a …
[HTML][HTML] Association of common genetic variants in pre-microRNAs and neuroblastoma susceptibility: a two-center study in Chinese children
Neuroblastoma is a commonly occurring extracranial pediatric solid tumor without defined
etiology. Polymorphisms in pre-miRNAs have been demonstrated to associate with the risk …
etiology. Polymorphisms in pre-miRNAs have been demonstrated to associate with the risk …
[HTML][HTML] The TP53 gene rs1042522 C> G polymorphism and neuroblastoma risk in Chinese children
TP53, a tumor suppressor gene, plays a critical role in cell cycle control, apoptosis, and DNA
damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 …
damage repair. Previous studies have indicated that the TP53 gene Arg72Pro (rs1042522 …
Fine mapping of 2q35 high‐risk neuroblastoma locus reveals independent functional risk variants and suggests full‐length BARD1 as tumor‐suppressor
F Cimmino, M Avitabile, SJ Diskin… - … Journal of Cancer, 2018 - Wiley Online Library
A previous genome‐wide association study (GWAS) identified common variation at the
BARD1 locus as being highly associated with susceptibility to high‐risk neuroblastoma, but …
BARD1 locus as being highly associated with susceptibility to high‐risk neuroblastoma, but …
[HTML][HTML] Dualistic role of BARD1 in cancer
F Cimmino, D Formicola, M Capasso - Genes, 2017 - mdpi.com
BRCA1 Associated RING Domain 1 (BARD1) encodes a protein which interacts with the N-
terminal region of BRCA1 in vivo and in vitro. The full length (FL) BARD1 mRNA includes 11 …
terminal region of BRCA1 in vivo and in vitro. The full length (FL) BARD1 mRNA includes 11 …
[HTML][HTML] Association between NER pathway gene polymorphisms and Wilms tumor risk
Nucleotide excision repair (NER) is an essential mechanism of the body to defend against
exogenous carcinogen-induced DNA damage. Defects in NER may impair DNA repair …
exogenous carcinogen-induced DNA damage. Defects in NER may impair DNA repair …