[HTML][HTML] Scale-up of micro-and milli-reactors: An overview of strategies, design principles and applications
Continuous-flow microreactor technology has been embraced by researchers in academia
and industry due to its excellent transport properties and the increased safety and control …
and industry due to its excellent transport properties and the increased safety and control …
The hitchhiker's guide to flow chemistry∥
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …
stream rather than in a flask. Flow equipment provides chemists with unique control over …
Emerging trends in flow chemistry and applications to the pharmaceutical industry
AR Bogdan, AW Dombrowski - Journal of medicinal chemistry, 2019 - ACS Publications
The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …
This Perspective highlights many recent advances in the field of flow chemistry and …
A review of microreactors based on slurry Taylor (segmented) flow
Microreactors with millimetric internal dimensions offer precise control over temperature,
flow and reaction, providing excellent system performance in terms of overall mixing …
flow and reaction, providing excellent system performance in terms of overall mixing …
Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant
M Berton, JM de Souza, I Abdiaj, DT McQuade… - Journal of Flow …, 2020 - Springer
The signature benefits of continuous flow are largely a result of a reactor's micro-sized
features. However, as the technology gains industrial traction in the synthesis of active …
features. However, as the technology gains industrial traction in the synthesis of active …
A machine learning-enabled process optimization of ultra-fast flow chemistry with multiple reaction metrics
Discovering the optimum process parameters of ultra-fast reactions, such as lithium–
halogen exchange reactions, is typically achieved by time and resource inefficient methods …
halogen exchange reactions, is typically achieved by time and resource inefficient methods …
Flow chemistry in contemporary chemical sciences: A real variety of its applications
M Trojanowicz - Molecules, 2020 - mdpi.com
Flow chemistry is an area of contemporary chemistry exploiting the hydrodynamic conditions
of flowing liquids to provide particular environments for chemical reactions. These particular …
of flowing liquids to provide particular environments for chemical reactions. These particular …
Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc (0)
The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith
reaction is herein described. Harnessing the use of mechanochemical techniques to activate …
reaction is herein described. Harnessing the use of mechanochemical techniques to activate …
[HTML][HTML] Incorporative mixing in microreactors: Influence on reactions and importance of inlet designation
S Asano, T Maki, S Inoue, S Sogo, M Furuta… - Chemical Engineering …, 2023 - Elsevier
Fast mixing is an essential feature of a microreactor. This study reveals the critical role of
microscopic fluid incorporation on fast chemical reactions in a microreactor. The vortices in a …
microscopic fluid incorporation on fast chemical reactions in a microreactor. The vortices in a …
Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir
T von Keutz, JD Williams, CO Kappe - Organic Process Research …, 2020 - ACS Publications
As remdesivir is the first approved treatment for COVID-19 (SARS-CoV-2), its production is
likely to be of vital importance in the near future. Continuous flow processing has been …
likely to be of vital importance in the near future. Continuous flow processing has been …