[HTML][HTML] Scale-up of micro-and milli-reactors: An overview of strategies, design principles and applications

Z Dong, Z Wen, F Zhao, S Kuhn, T Noël - Chemical Engineering Science: X, 2021 - Elsevier
Continuous-flow microreactor technology has been embraced by researchers in academia
and industry due to its excellent transport properties and the increased safety and control …

The hitchhiker's guide to flow chemistry∥

MB Plutschack, B Pieber, K Gilmore… - Chemical …, 2017 - ACS Publications
Flow chemistry involves the use of channels or tubing to conduct a reaction in a continuous
stream rather than in a flask. Flow equipment provides chemists with unique control over …

Emerging trends in flow chemistry and applications to the pharmaceutical industry

AR Bogdan, AW Dombrowski - Journal of medicinal chemistry, 2019 - ACS Publications
The field of flow chemistry has garnered considerable attention over the past 2 decades.
This Perspective highlights many recent advances in the field of flow chemistry and …

A review of microreactors based on slurry Taylor (segmented) flow

Z Peng, G Wang, B Moghtaderi, E Doroodchi - Chemical Engineering …, 2022 - Elsevier
Microreactors with millimetric internal dimensions offer precise control over temperature,
flow and reaction, providing excellent system performance in terms of overall mixing …

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

M Berton, JM de Souza, I Abdiaj, DT McQuade… - Journal of Flow …, 2020 - Springer
The signature benefits of continuous flow are largely a result of a reactor's micro-sized
features. However, as the technology gains industrial traction in the synthesis of active …

A machine learning-enabled process optimization of ultra-fast flow chemistry with multiple reaction metrics

D Karan, G Chen, N Jose, J Bai, P McDaid… - Reaction Chemistry & …, 2024 - pubs.rsc.org
Discovering the optimum process parameters of ultra-fast reactions, such as lithium–
halogen exchange reactions, is typically achieved by time and resource inefficient methods …

Flow chemistry in contemporary chemical sciences: A real variety of its applications

M Trojanowicz - Molecules, 2020 - mdpi.com
Flow chemistry is an area of contemporary chemistry exploiting the hydrodynamic conditions
of flowing liquids to provide particular environments for chemical reactions. These particular …

Mechanochemical Simmons–Smith cyclopropanation via ball-milling-enabled activation of zinc (0)

L Pontini, JA Leitch, DL Browne - Green Chemistry, 2023 - pubs.rsc.org
The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons–Smith
reaction is herein described. Harnessing the use of mechanochemical techniques to activate …

[HTML][HTML] Incorporative mixing in microreactors: Influence on reactions and importance of inlet designation

S Asano, T Maki, S Inoue, S Sogo, M Furuta… - Chemical Engineering …, 2023 - Elsevier
Fast mixing is an essential feature of a microreactor. This study reveals the critical role of
microscopic fluid incorporation on fast chemical reactions in a microreactor. The vortices in a …

Continuous Flow C-Glycosylation via Metal–Halogen Exchange: Process Understanding and Improvements toward Efficient Manufacturing of Remdesivir

T von Keutz, JD Williams, CO Kappe - Organic Process Research …, 2020 - ACS Publications
As remdesivir is the first approved treatment for COVID-19 (SARS-CoV-2), its production is
likely to be of vital importance in the near future. Continuous flow processing has been …