The gastrointestinal tract plays a role in the development and treatment of metabolic
diseases. During a meal, the gut provides crucial information to the brain regarding …

Gut hormones have many key roles in the control of metabolism, as they target diverse
tissues involved in the control of intestinal function, insulin secretion, nutrient assimilation …

Background & Aims Single-cell transcriptomics offer unprecedented resolution of tissue
function at the cellular level, yet studies analyzing healthy adult human small intestine and …

Gut hormones orchestrate pivotal physiological processes in multiple metabolically active
tissues, including the pancreas, liver, adipose tissue, gut and central nervous system …

The efficacy of Roux-en-Y gastric-bypass (RYGB) and other bariatric surgeries in the
management of obesity and type 2 diabetes mellitus and novel developments in …

Understanding the development and function of an organ requires the characterization of all
of its cell types. Traditional methods for visualizing and isolating subpopulations of cells are …

Homeostatic regulation of the intestinal enteroendocrine lineage hierarchy is a poorly
understood process. We resolved transcriptional changes during enteroendocrine …

Drug delivery systems or vectors are usually needed to improve the bioavailability and
effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an …

Several cell populations have been reported to possess intestinal stem cell (ISC) activity
during homeostasis and injury-induced regeneration. Here, we explored inter-relationships …

The enteroendocrine system orchestrates how the body responds to the ingestion of foods,
employing a diversity of hormones to fine-tune a wide range of physiological responses both …