Conspectus Ynamides are electron-rich heteroatom-substituted alkynes with a C–C triple
bond directly attached to the amide group. Importantly, this amide group is able to impose an …

Catalytic transformations involving metal carbenes are considered one of the most important
aspects of homogeneous transition metal catalysis. Recently, gold-catalyzed generation of …

Over the past two decades, the development and application of ynamide chemistry have
received more and more attention. Ynamides have proven to be versatile reagents for …

Three-and four-membered rings, widespread motifs in nature and medicinal chemistry, have
fascinated chemists ever since their discovery. However, due to energetic considerations …

Ynamides are among the most powerful building blocks in organic synthesis and have
become invaluable starting materials for the construction of multifunctional compounds and …

Ynamides are unique alkynes with a carbon–carbon triple bond directly attached to the
nitrogen atom bearing an electron-withdrawing group. The alkyne is strongly polarized by …

Synthesis of bicyclic scaffolds has gained significant attention in drug discovery due to their
potential to mimic benzene bioisosteres. Here, we present a mild and scalable Sc (OTf) 3 …

Silver is a less expensive noble metal. Superior alkynophilicity due to π-coordination with
the carbon–carbon triple bond makes silver salts ideal catalysts for alkyne-based organic …

In recent years, asymmetric catalysis of ynamides has attracted much attention, but these
reactions mostly constructed central chirality, except for a few examples on the synthesis of …

Chiral Brønsted acid-catalysed asymmetric synthesis has received tremendous interest over
the past decades, and numerous efficient synthetic methods have been developed based on …