Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to
transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either triggers …

Abstract The PI3K/Akt signal transduction cascade has been investigated extensively for its
roles in oncogenic transformation. Initial studies implicated both PI3K and Akt in prevention …

Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome
inhibitor, bortezomib, selectively induces apoptosis in MM cells; however, the nature of its …

Among cell cycle regulatory proteins that are activated following DNA damage, the cyclin-
dependent kinase inhibitor p21CDKN1A plays essential roles in the DNA damage response …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

As formulated in 1974, the concept of the restriction point of the cell cycle was based on cell
biological experiments, yet allowing accurate molecular predictions and spurring a search …

In addition to its diverse role in many physiological systems, zinc (Zn) has now been shown
to be an important regulator of apoptosis. The purpose of this review is to integrate …

It has been discovered that proteasome inhibitors are able to induce tumor growth arrest or
cell death and that tea consumption is correlated with cancer prevention. Here, we show that …

p21WAF1/CIP1 is a broad-acting cyclin-dependent kinase inhibitor. Its stability is essential
for proper cell-cycle progression and cell fate decision. Ubiquitylation by the multiple E3 …

In this paper we present the finding that lovastatin arrests cells by inhibiting the proteasome,
which results in the accumulation of p21 and p27, leading to G1 arrest. Lovastatin is an …