The spinocerebellar ataxias (SCAs) comprise more than 40 autosomal dominant
neurodegenerative disorders that present principally with progressive ataxia. Within the past …

Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …

Background Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of
autosomal dominantly inherited spinocerebellar ataxias (SCAs). No validated blood …

Background and purpose Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require
biomarkers for use as outcome measures. Methods To evaluate total tau (t‐tau), glial …

The spinocerebellar ataxias (SCAs) are a group of dominantly inherited diseases that share
the defining feature of progressive cerebellar ataxia. The disease process, however, is not …

Recent advances in understanding dominant spinocerebellar ataxias from clinical and
genetic points of view - PMC Back to Top Skip to main content NIH NLM Logo Access keys …

Background The role of peripheral inflammation in spinocerebellar ataxia type 2 (SCA2) is
unknown. Objective The objective of this study was to identify peripheral inflammation …

Spinocerebellar ataxia type 3 (SCA3) is the most common type of disease related to poly-
glutamine (polyQ) repeats. Its hallmark pathology is related to the abnormal accumulation of …

Objectives Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a
polyglutamine disorder with no current disease-modifying treatment. Conformational …

Spinocerebellar ataxia type 3/Machado–Joseph disease (SCA3/MJD) is a progressive motor
disease with no broadly effective treatment. However, most current therapies are based on …