[HTML][HTML] Ribonucleotide reductases: essential enzymes for bacterial life
E Torrents - Frontiers in cellular and infection microbiology, 2014 - frontiersin.org
Ribonucleotide reductase (RNR) is a key enzyme that mediates the synthesis of
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
deoxyribonucleotides, the DNA precursors, for DNA synthesis in every living cell. This …
Class I ribonucleotide reductases: metallocofactor assembly and repair in vitro and in vivo
JA Cotruvo Jr, JA Stubbe - Annual review of biochemistry, 2011 - annualreviews.org
Incorporation of metallocofactors essential for the activity of many enyzmes is a major
mechanism of posttranslational modification. The cellular machinery required for these …
mechanism of posttranslational modification. The cellular machinery required for these …
[HTML][HTML] VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins
BA Ahidjo, D Kuhnert, JL McKenzie, EE Machowski… - PloS one, 2011 - journals.plos.org
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin
modules belonging to the VapBC family. The role of these modules in the physiology of Mtb …
modules belonging to the VapBC family. The role of these modules in the physiology of Mtb …
Vitamin B12 Metabolism in Mycobacterium Tuberculosis
Mycobacterium tuberculosis is included among a select group of bacteria possessing the
capacity for de novo biosynthesis of vitamin B12, the largest and most complex natural …
capacity for de novo biosynthesis of vitamin B12, the largest and most complex natural …
[HTML][HTML] Monitoring global protein thiol-oxidation and protein S-mycothiolation in Mycobacterium smegmatis under hypochlorite stress
Mycothiol (MSH) is the major low molecular weight (LMW) thiol in Actinomycetes. Here, we
used shotgun proteomics, OxICAT and RNA-seq transcriptomics to analyse protein S …
used shotgun proteomics, OxICAT and RNA-seq transcriptomics to analyse protein S …
[HTML][HTML] Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase
CM Zimanyi, N Ando, EJ Brignole, FJ Asturias… - Structure, 2012 - cell.com
Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair
and are successful targets for anticancer drugs such as clofarabine and gemcitabine …
and are successful targets for anticancer drugs such as clofarabine and gemcitabine …
[HTML][HTML] Phylogenetic analysis of vitamin B12-related metabolism in Mycobacterium tuberculosis
DB Young, I Comas, LPS de Carvalho - Frontiers in molecular …, 2015 - frontiersin.org
Comparison of genome sequences from clinical isolates of Mycobacterium tuberculosis with
phylogenetically-related pathogens Mycobacterium marinum, Mycobacterium kansasii, and …
phylogenetically-related pathogens Mycobacterium marinum, Mycobacterium kansasii, and …
Role of the DinB Homologs Rv1537 and Rv3056 in Mycobacterium tuberculosis
The environment encountered by Mycobacterium tuberculosis during infection is genotoxic.
Most bacteria tolerate DNA damage by engaging specialized DNA polymerases that …
Most bacteria tolerate DNA damage by engaging specialized DNA polymerases that …
Functional Analysis of Molybdopterin Biosynthesis in Mycobacteria Identifies a Fused Molybdopterin Synthase in Mycobacterium tuberculosis
Most mycobacterial species possess a full complement of genes for the biosynthesis of
molybdenum cofactor (MoCo). However, a distinguishing feature of members of the …
molybdenum cofactor (MoCo). However, a distinguishing feature of members of the …
DNA Replication in Mycobacterium tuberculosis
Z Ditse, MH Lamers, DF Warner - Microbiology spectrum, 2017 - Am Soc Microbiol
Faithful replication and maintenance of the genome are essential to the ability of any
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …
organism to survive and propagate. For an obligate pathogen such as Mycobacterium …