Microphysiological systems (MPS) are powerful tools for emulating human physiology and
replicating disease progression in vitro. MPS could be better predictors of human outcome …

Background Studies of cell-to-cell variation have in recent years grown in interest, due to
improved bioanalytical techniques which facilitates determination of small changes with high …

Recent and rapidly evolving progress on high-throughput measurement techniques and
computational performance has led to the emergence of new disciplines, such as systems …

We are currently in the middle of a major shift in biomedical research: unprecedented and
rapidly growing amounts of data may be obtained today, from in vitro, in vivo and clinical …

Mitochondrial diseases are mainly caused by dysfunction of mitochondrial respiratory chain
complexes and have a variety of genetic variants or phenotypes. There are only a few …

Adiponectin is a hormone secreted from white adipocytes and takes part in the regulation of
several metabolic processes. Although the pathophysiological importance of adiponectin …

Functional magnetic resonance imaging (fMRI) measures brain activity by detecting the
blood-oxygen-level dependent (BOLD) response to neural activity. The BOLD response …

Abstract Purpose or Objective Drug concentration–response curves (DRCs) are crucial in
pharmacology for assessing the drug effects on biological systems. The widely used sigmoid …

Lipolysis and the release of fatty acids to supply energy fuel to other organs, such as
between meals, during exercise, and starvation, are fundamental functions of the adipose …

Pharmaceutical induction of metabolically active beige adipocytes in the normally energy
storing white adipose tissue has potential to reduce obesity. Mitochondrial uncoupling in …