Modulating Treg stability to improve cancer immunotherapy
JH Kang, R Zappasodi - Trends in cancer, 2023 - cell.com
Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …
Cancer metabolism and tumor microenvironment: fostering each other?
The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …
Lack of CD8+ T cell effector differentiation during priming mediates checkpoint blockade resistance in non–small cell lung cancer
In non–small cell lung cancer (NSCLC), response to immune checkpoint blockade (ICB) is
associated with programmed cell death ligand 1 expression that is induced by interferon-γ …
associated with programmed cell death ligand 1 expression that is induced by interferon-γ …
[HTML][HTML] Landscape of stimulation-responsive chromatin across diverse human immune cells
D Calderon, MLT Nguyen, A Mezger, A Kathiria… - Nature …, 2019 - nature.com
A hallmark of the immune system is the interplay among specialized cell types transitioning
between resting and stimulated states. The gene regulatory landscape of this dynamic …
between resting and stimulated states. The gene regulatory landscape of this dynamic …
Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis, and immunotherapy
The PI3K pathway is hyperactivated in most cancers, yet the capacity of PI3K inhibitors to
induce tumor cell death is limited. The efficacy of PI3K inhibition can also derive from …
induce tumor cell death is limited. The efficacy of PI3K inhibition can also derive from …
Reprogramming T cell differentiation and exhaustion in CAR-T cell therapy
Y Bulliard, BS Andersson, MA Baysal… - Journal of hematology & …, 2023 - Springer
T cell differentiation is a highly regulated, multi-step process necessary for the progressive
establishment of effector functions, immunological memory, and long-term control of …
establishment of effector functions, immunological memory, and long-term control of …
SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation
X Yu, Y Lao, XL Teng, S Li, Y Zhou, F Wang… - Nature …, 2018 - nature.com
Regulatory T (Treg) cells are essential for maintaining immune homeostasis and tolerance,
but the mechanisms regulating the stability and function of Treg cells have not been fully …
but the mechanisms regulating the stability and function of Treg cells have not been fully …
[HTML][HTML] BACH transcription factors in innate and adaptive immunity
K Igarashi, T Kurosaki, R Roychoudhuri - Nature Reviews Immunology, 2017 - nature.com
Abstract BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic
region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread …
region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread …
The Bach family of transcription factors: a comprehensive review
Y Zhou, H Wu, M Zhao, C Chang, Q Lu - Clinical reviews in allergy & …, 2016 - Springer
The transcription factors Bach1 and Bach2, which belong to a basic region-leucine zipper
(bZip) family, repress target gene expression by forming heterodimers with small Maf …
(bZip) family, repress target gene expression by forming heterodimers with small Maf …